全文获取类型
收费全文 | 397893篇 |
免费 | 26878篇 |
国内免费 | 8687篇 |
专业分类
耳鼻咽喉 | 4287篇 |
儿科学 | 10827篇 |
妇产科学 | 7142篇 |
基础医学 | 32360篇 |
口腔科学 | 9117篇 |
临床医学 | 42992篇 |
内科学 | 48971篇 |
皮肤病学 | 5118篇 |
神经病学 | 22146篇 |
特种医学 | 8824篇 |
外国民族医学 | 35篇 |
外科学 | 41396篇 |
综合类 | 61425篇 |
现状与发展 | 14篇 |
一般理论 | 44篇 |
预防医学 | 44914篇 |
眼科学 | 6526篇 |
药学 | 35184篇 |
460篇 | |
中国医学 | 35869篇 |
肿瘤学 | 15807篇 |
出版年
2023年 | 6116篇 |
2022年 | 9251篇 |
2021年 | 15283篇 |
2020年 | 14451篇 |
2019年 | 20867篇 |
2018年 | 18360篇 |
2017年 | 14986篇 |
2016年 | 12162篇 |
2015年 | 11515篇 |
2014年 | 23799篇 |
2013年 | 25370篇 |
2012年 | 21705篇 |
2011年 | 23741篇 |
2010年 | 19492篇 |
2009年 | 17278篇 |
2008年 | 16697篇 |
2007年 | 17168篇 |
2006年 | 15027篇 |
2005年 | 12951篇 |
2004年 | 10476篇 |
2003年 | 9166篇 |
2002年 | 7178篇 |
2001年 | 6410篇 |
2000年 | 5344篇 |
1999年 | 4610篇 |
1998年 | 3743篇 |
1997年 | 3599篇 |
1996年 | 2824篇 |
1995年 | 2866篇 |
1994年 | 2781篇 |
1993年 | 2226篇 |
1992年 | 2215篇 |
1991年 | 1922篇 |
1990年 | 1701篇 |
1989年 | 1523篇 |
1988年 | 1417篇 |
1987年 | 1226篇 |
1985年 | 4316篇 |
1984年 | 5495篇 |
1983年 | 3862篇 |
1982年 | 4376篇 |
1981年 | 4107篇 |
1980年 | 3687篇 |
1979年 | 3517篇 |
1978年 | 3118篇 |
1977年 | 2337篇 |
1976年 | 2693篇 |
1975年 | 2135篇 |
1974年 | 1871篇 |
1973年 | 1739篇 |
排序方式: 共有10000条查询结果,搜索用时 187 毫秒
91.
92.
93.
94.
95.
Ki-Yong An Andria R. Morielli Dong-Woo Kang Christine M. Friedenreich Donald C. McKenzie Karen Gelmon John R. Mackey Robert D. Reid Kerry S. Courneya 《International journal of cancer. Journal international du cancer》2020,146(1):150-160
The Combined Aerobic and Resistance Exercise (CARE) Trial compared different types and doses of exercise performed during breast cancer chemotherapy. Here, we report the longer-term follow-up of patient-reported outcomes, health-related fitness and exercise behavior at 6, 12 and 24 months postintervention. A multicenter trial in Canada randomized 301 breast cancer patients initiating chemotherapy to thrice weekly, supervised exercise consisting of a standard dose of 25–30 min of aerobic exercise (STAN; n = 96), a higher dose of 50–60 min of aerobic exercise (HIGH; n = 101) or a combined dose of 50–60 min of aerobic and resistance exercise (COMB; n = 104) performed for the duration of chemotherapy (median of 17 weeks). Primary outcomes were patient-reported outcomes including quality of life, cancer-related symptoms and psychosocial outcomes. Secondary outcomes were objective health-related fitness (assessed at 12 months only) and self-reported exercise behavior. A total of 269 (89.4%) participants completed patient-reported outcomes at all three follow-up time points and 263 (87.4%) completed the health-related fitness assessment at 12-month follow-up. COMB was significantly superior to (i) STAN for sleep quality at 6-month follow-up (p = 0.027); (ii) HIGH for upper body muscular endurance at 12-month follow-up (p = 0.020); and (iii) HIGH for meeting the resistance exercise guideline at 6-month follow-up (p = 0.006). Moreover, self-reported meeting of the combined exercise guideline during follow-up was significantly associated with better patient-reported outcomes and health-related fitness. Performing combined exercise during and after breast cancer chemotherapy may result in better longer-term patient-reported outcomes and health-related fitness compared to performing aerobic exercise alone. 相似文献
96.
邵凤霞 《中国继续医学教育》2020,(7):190-192
目的探讨中西医结合护理改善老年高血压患者心理状态及生活质量的效果。方法在医院2018年1月—2018年6月就诊的老年高血压患者中选出60例,按照随机数字法的原则,分成研究组(n=30)和参考组(n=30)。参考组采用单一西医护理,研究组在此之外联合中医护理,比较两组患者的临床疗效。结果入院时研究组与参考组SAS、SDS、SF-6评分差异不显著(P>0.05),护理后1月、3月与参考组相比,研究组SAS、SDS评分显著降低(P<0.05),SF-6评分显著升高(P<0.05);研究组患者对中西结合护理满意度为96.67%,参考组患者对西医护理满意度为73.33%,研究组满意度较参考组高,差异显著(P<0.05)。结论中西医结合护理能够有效改善老年高血压患者的心理状态,提高生活质量。 相似文献
97.
Nidogen 1 (NID1) is a glycoprotein found in basement membranes involved in cross-linking collagen IV and laminin. The role of NID in breast cancer has only been evaluated in a small number of studies and the findings of these studies have been inconsistent. Our previous work revealed that highly tumorigenic murine mammary tumor cells express high levels of Nid1 while weakly tumorigenic mammary tumor cells express low levels of Nid1. To investigate Nid1, two stable knockdown lines were created, and Nid1 knockdown was confirmed at both the mRNA and protein level. Nid1 knockdown significantly reduced cell proliferation and migration/invasion and these reductions in proliferation and migration/invasion could be rescued by conditioned media containing NID1 protein. The reduced migration/invasion observed in the Nid1 knockdown cells was not associated with significant alterations in the epithelial gene Cdh1 or the mesenchymal genes Snai1, Snai2, Twist1, Twist2, Zeb1 and Zeb2. Therefore, suppression of Nid1 expression reduces proliferation and migration/invasion in claudin-low murine mammary tumor cells. 相似文献
98.
目的探讨分诊安全管理结合风险管理提高急诊科护理质量评分的作用。方法该院于2018年6月起加强对急诊科的分诊安全管理结合风险管理,以于2017年6月—2019年6月在该院急诊科就诊的患者为研究对象,评价管理策略实施前后护理风险发生率、护理质量评分以及患者满意度等评价指标变化情况。结果实施后基础护理、实践操作、消毒隔离、急救药品、护理文件方面的护理质量评分均较实施前显著提高(P<0.05);实施后护理差错、护理缺陷、护理投诉的发生率分别为0.26%、0.58%、0.19%,均较实施前显著降低(P<0.05);实施后护理总满意率为94.92%,较实施前显著提高(P<0.05)。结论分诊安全管理结合风险管理有效提高了急诊科护理质量,提升了患者满意度,减少了护理风险事件的发生。 相似文献
99.
100.
《Journal of the American Medical Directors Association》2020,21(4):531-537.e1
ObjectiveHospitalization-associated disability [HAD, ie, the loss of ability to perform ≥1 basic activities of daily living (ADLs) independently at discharge] is a frequent condition among older patients. The present study assessed whether a simple inpatient exercise program decreases HAD incidence in acutely hospitalized very old patients.DesignIn this randomized controlled trial (Activity in Geriatric Acute Care) participants were assigned to a control or intervention group and were assessed at baseline, admission, discharge, and 3 months thereafter.Setting and ParticipantsIn total, 268 patients (mean age 88 years, range 75–102) admitted to an acute care for older patients unit of a public hospital were randomized to a control (n = 125) or intervention (exercise) group (n = 143).MethodsBoth groups received usual care, and patients in the intervention group also performed simple supervised exercises (walking and rising from a chair, for a total duration of ∼20 minutes/day). We measured ADL function (Katz index) and incident HAD at discharge and after 3 months (primary outcome) and Short Physical Performance Battery, ambulatory capacity, number of falls, rehospitalization, and death during a 3-month follow-up (secondary outcomes).ResultsMedian duration of hospitalization was 7 days (interquartile range 4 days). The intervention group had a lower risk of HAD with reference to both baseline [odds ratio (OR) 0.36; 95% confidence interval (CI) 0.17–0.76, P = .007] and admission (OR 0.29; 95% CI 0.10–0.89, P = .030). A trend toward an improved ADL function at discharge vs admission was found in the intervention group compared with controls (OR 0.32; 95% CI ‒0.04 to 0.68; P = .083). No between-group differences were noted for the other endpoints (all P > .05).Conclusion and ImplicationsA simple inpatient exercise program decreases risk of HAD in acutely hospitalized, very old patients. 相似文献